Reading boss Ruben Selles has made just one change from the team that drew 1-1 with Lincoln City last week, with captain Andy Yiadom dropping out.
The Royals are just four points adrift of safety and face a Wigan Athletic side sat 17th in League One.
With one defeat in five matches, the side will be looking to make some ground up on the relegation rivals around them.
David Button remains in the net, with a back four of Amadou Mbengue, Tom Holmes, Nelson Abbey and Jeriel Dorsett.
Michael Craig, Harvey Knibbs and Lewis Wing will look to dictate play, feeding Femi Azeez, Sam Smith and Paul Mukairu.
Ben Elliott, Charlie Savage and Kelvin Ehibhatiomhan provide options off the bench.
2013 FA Cup winner Callum McMananman plays for the Latics, while Charlie Wyke starts up front.
Comments: Our rules
We want our comments to be a lively and valuable part of our community - a place where readers can debate and engage with the most important local issues. The ability to comment on our stories is a privilege, not a right, however, and that privilege may be withdrawn if it is abused or misused.
Please report any comments that break our rules.
Read the rules here