Noel Hunt has given Academy graduate Kelvin Ehibhatiomhan his first league start.
Taking over from Paul Ince during the week, the Under-21 manager has been given interim charge until the end of the season.
Inside the bottom three, and facing champions-elect Burnley, the demand for points is heightened.
Making three changes from the side that lost 2-1 to Preston North End, Andy Carroll, Amadou Mbengue and Mamadou Loum drop to the bench.
Youngsters Femi Azeez, Ehibhatiomhan and Tyrese Fornah come in from the start.
Fellow Under-21s Coniah Boyce-Clarke, Mamadi Camara and Kelvin Abrefa are on the bench.
Lumley; Yiadom; Holmes; Sarr; Guinness-Walker; Fornah; Hendrick; Casadei; Azeez; Joao; Ehibhatiomhan
π¨ ππππ ππππ π¨
β Reading FC (@ReadingFC) April 15, 2023Β
The Royals make 3οΈβ£ changes from their last match ποΈ
π«‘ A first league start for @Kelvinehi10 who partners Lucas Joao β½
π Femi Azeez and @TyreseFornah come into the sideπ#REABUR pic.twitter.com/0mvWr0TKYr
Share