Paul Ince has made three changes for the trip to Stoke City, with Tyrese Fornah returning from injury to start in Staffordshire.
Yakou Meite and Tom McIntyre complete the changes, with Naby Sarr, Andy Carroll and Sam Hutchinson taken out.
Last season's top scorer, Lucas Joao, has a place on the bench.
Lumley; Holmes; McIntyre; Hendrick; Ince; Meite; Baba; Yiadom; Fornah; Loum; Hoilett
For the hosts, former Royals Lewis Baker and Josh Laurent sit in the Potters' midfield.
Phil Jagielka, who first came across Reading over 20 years ago, is still going strong in defence.
Dwight Gayle and Tyrese Campbell lead the line, a formidable strike-force for the hosts.
Bondham; Fox; Jagielka; Baker; Brown; Campbell; Gayle; Tymon; Wilmot; Smallbone; Laurent
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