All lines between Reading and Swindon are blocked after a person was hit by a train.
Great Western Railway has said that the emergency incident means that disruption is expected along the route for much of the afternoon.
A spokesperson said: "Due to the emergency services dealing with an incident between Swindon and Reading the line is blocked.
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"Train services running to and from these stations may be cancelled or delayed. Disruption is expected until 4.30pm."
The railway company has confirmed that a "person has been struck by a train" and that services in the area have been brought to an immediate stop.
The spokesperson added: "If you are onboard one of the services in this incident and have been affected by this incident or know someone else who needs support, there is always someone to talk to.
"Contact a Samaritan on 116 123 for free, any time, on any phone. Help is only a phone call away."
The company said they were working with Network Rail to deal with the incident "as sensitively, quickly and safely as possible".
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They said: "Your journey is likely to be delayed and could take up to 90 minutes longer to complete.
"Some trains will be revised, only completing parts of their normal journeys, and there will also be some cancellations.
"To avoid trains being stopped for a long time outside of a station, some of our longer distance trains may be held in station platforms some distance away from the affected area."
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