Fire engines were called from nine different stations to tackle a blaze which ignited several homes in Calcot overnight.
Royal Berkshire Fire and Rescue Service have confirmed that two properties in Red Cottage Drive were affected by the fire, but aerial photographs appear to show damage to four buildings.
It is also unclear home many homes were in each property, but numerous people have been evacuated and a triage centre was set up in Calcot Nursery.
LIVE: Major incident as fire destroys homes and residents are evacuated
Crews remain on the scene dampening down areas and carrying our reinspections.
The incident is scaling back but residents are advised to avoid the area, according to Royal Berkshire Fire Service.
Four firefighters wearing breathing apparatus worked from 11.47pm to extinguish the fire using two hose reels and two main jets.
Fire engines were called from Newbury Fire Station, and a crew from Theale, Caversham Road, Whitley Wood, Wokingham Road, Mortimer, Bracknell, Crowthorne, and Maidenhead.
They were joined by an Aerial Ladder Platform from Whitley Wood Fire Station, the Incident Command Unit from Maidenhead Fire Station and two RBFRS Officers.
Royal Berkshire Fire and Rescue Service declined to comment on the cause of the fire at this time.
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